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Melatonin

Melatonin

Item no.	HY-B0075-10mM
Manufacturer	MedChem Express
CASRN	73-31-4
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665\|[2]Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1\|[3]Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31\|[4]Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.\|[5]Zhi Chen, et al. Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res. 2019 May 10;12(1):43.
Smiles	CC(NCCC1=CNC2=C1C=C(OC)C=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	N-Acetyl-5-methoxytryptamine
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; Autophagy; Endogenous Metabolite; Melatonin Receptor; Mitophagy
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	232.28
Product Description	Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|Ethanol: 12.5 mg/mL (ultrasonic)\|H2O: 1.1 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	Human Endogenous Metabolite; Microbial Metabolite
Clinical information	Launched

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HY-B0075-10mM-safety-datasheet.pdf