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Bisoprolol (hemifumarate)

Bisoprolol (hemifumarate)

Item no.	HY-B0076-500mg
Manufacturer	MedChem Express
CASRN	104344-23-2
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 200 mg 250 mg 500 mg 50 mg
Category	Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.84
Citations	[1]Jillian G Baker, et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22. \|[2]Jing Wang, et al. Bisoprolol, a β 1 antagonist, protects myocardial cells from ischemia-reperfusion injury via PI3K/AKT/GSK3β pathway. Fundam Clin Pharmacol. 2020 Dec;34(6):708-720. \|[3]Hong Yang, et al. Bisoprolol reverses epinephrine-mediated inhibition of cell emigration through increases in the expression of β-arrestin 2 and CCR7 and PI3K phosphorylation, in dendritic cells loaded with cholesterol. Thromb Res. 2013 Mar;131(3):230-7. \|[4]Jinhua Liu, et al. Protective Effects of Bisoprolol Against Cadmium-induced Myocardial Toxicity Through Inhibition of Oxidative Stress and NF-κΒ Signalling in Rats. J Vet Res. 2021 Oct 20;65(4):505-511. \|[5]Yajuan Ni, et al. Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model. Mol Cell Biochem. 2013 Dec;384(1-2):95-103. Am J Respir Cell Mol Biol. 2023 May 10.\|Cell Rep. 2024 May 31;43(6):114302.\|Int J Mol Sci. 2023 Aug 9, 24(16), 12609.\|Mol Neurobiol. 2019 Jan;56(1):367-377. \|ACS Omega. 2022 Aug 8;7(32):27950-27958.\|J Pharmaceut Biomed. 2020, 113870.
Smiles	OC(CNC(C)C)COC1=CC=C(COCCOC(C)C)C=C1.OC(/C=C/C(O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	104344-23-2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	383.48
Product Description	Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].
Manufacturer - Research Area	Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO: ≥ 50 mg/mL\|H2O: 20 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	β adrenergic receptor
Clinical information	Launched

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HY-B0076-500mg-safety-datasheet.pdf