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Fenoprofen (Calcium hydrate)

Fenoprofen (Calcium hydrate)

Item no.	HY-B0288B-10mM
Manufacturer	MedChem Express
CASRN	71720-56-4
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.69
Citations	[1]Yuan XC, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10(3):1066-1074. \|[2]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74(7):1335-1345.
Smiles	CC(C([O-])=O)C1=CC(OC2=CC=CC=C2)=CC=C1.O.[0.5Ca2+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LILLY-53858 (Calcium hydrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	COX; ERK; Melanocortin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	279.32
Product Description	Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: ≥ 100 mg/mL\|H2O: 1 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Isoform	COX
Clinical information	Launched

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HY-B0288B-10mM-safety-datasheet.pdf