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Clemastine (fumarate)

Clemastine (fumarate)

Item no.	HY-B0298A-100mg
Manufacturer	MedChem Express
CASRN	14976-57-9
Amount	100 mg
Quantity options	100 mg 10mM/1mL 200 mg 500 mg
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C25H30ClNO5
Citations	Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. Br J Pharmacol. 2025 Mar 7. Cell Prolif. 2021 Jan;54(1):e12953. Exp Neurol. 2024 Dec 3:115086. Microbiol Spectr. 2022 Mar 2;e0054121. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Nov 28:110901. Viruses. 2021 Jun 28;13(7):1255. Methods Mol Biol. 2023;2683:103-111. [1]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34. [2]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.
Smiles	CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HS-592 (fumarate); Meclastine (fumarate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Histamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	459.96
Product Description	Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
Manufacturer - Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 14.29 mg/mL (ultrasonic)\|H2O : 0.67 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H1 Receptor
Clinical information	Launched

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HY-B0298A-100mg-safety-datasheet.pdf