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Tioconazole

Tioconazole

Item no.	HY-B0319-10g
Manufacturer	MedChem Express
CASRN	65899-73-2
Amount	10 g
Quantity options	10 g 10 mM/1 mL 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]S P Clissold, et al. Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses. Drugs. 1986 Jan;31(1):29-51.\|[2]Yamamoto ES, et al. Activity of Fenticonazole, Tioconazole and Nystatin on New World Leishmania Species. Curr Top Med Chem. 2018;18(27):2338-2346.\|[3]Sebastian J, et al. Cytotoxic mechanism of tioconazole involves cell cycle arrest at mitosis through inhibition of microtubule assembly. Cytotechnology. 2022 Feb;74(1):141-162.\|[4]El-Gowily AH, et al. Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. Pharmaceuticals (Basel). 2021 Mar 11;14(3):254.\|[5]Liu PF, et al. Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics. 2018 Jan 1;8(3):830-845.
Smiles	ClC1=CC=C(C(OCC2=C(Cl)SC=C2)CN3C=CN=C3)C(Cl)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UK-20349
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Akt; Antibiotic; Autophagy; Fungal; mTOR; Parasite; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	387.71
Product Description	Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: ≥ 100 mg/mL\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	Anti-infection; Autophagy; PI3K/Akt/mTOR
Clinical information	Launched

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HY-B0319-10g-safety-datasheet.pdf