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Meclizine (dihydrochloride)

Meclizine (dihydrochloride)

Item no.	HY-B0349-5g
Manufacturer	MedChem Express
CASRN	1104-22-9
Amount	5 g
Quantity options	100 mg 10mM/1mL 5 g
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.95
Citations	Ren Fail. 2023 Dec;45(1):2230318. Am J Obstet Gynecol. 2024 Feb 15:S0002-9378(24)00088-7. [1]Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness. [2]Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20(2):294-300. [3]Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR [4] Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2(9):1090-101.
Smiles	CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Meclozine (dihydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Histamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	463.87
Product Description	Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].
Manufacturer - Research Area	Neurological Disease; Endocrinology; Cancer
Solubility	DMSO : ≥ 33.33 mg/mL
Manufacturer - Pathway	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H1 Receptor
Clinical information	Launched

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