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Ciprofloxacin (monohydrochloride)

Ciprofloxacin (monohydrochloride)

Item no.	HY-B0356A-1g
Manufacturer	MedChem Express
CASRN	93107-08-5
Amount	1 g
Quantity options	10 mMx1 mL 1 g 500 mg 5 g
Category	Oncology Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.90
Formula	C17H19ClFN3O3
Citations	ACS Appl Polym Mater. 2023 Aug 29. bioRxiv. 2024 Jan 18. Adv Sci (Weinh). 2020 Jul 21;7(17):2001374. Anal Chim Acta. 15 June 2022, 340082. Animal Diseases. 02 November 2021. Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. Arab J Chem. 2024 May, 17, 5, 105745. bioRxiv. 2024 May 10. bioRxiv. 2024 Nov 06. Cardiovasc Toxicol. 2024 Aug 13. Chemosphere. 2019 Jun;225:378-387. EBioMedicine. 2022 Apr;78:103943. Front Microbiol. 2022 Feb 16;12:773664. Genome Biol. 2023 Apr 30;24(1):98. Int J Antimicrob Agents. 2018 Aug;52(2):269-271. iScience. 2023 Oct 5. J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. Microb Pathog. 2024 Apr 27:106666. Microbiol Spectr. 2022 Apr 25:e0251821. Microbiol Spectr. 2022 Jan 12;e0099121. Molecules. 2023 Jun 8, 28(12), 4628. Nat Cell Biol. 2024 Jul 12. Nature. 2024 Aug;632(8027):1137-1144. NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. Orebro University. 2024. Patent. US20200101105A1. PLoS Pathog. 2024 Dec 31;20(12):e1012783. Research Square Preprint. 2020 Jun. Vet Microbiol. 2024 May, 292, 110046. Virulence. 2024 Oct 10:2415952. Water Res. 2023 May 21, 120110. Water Res. 2024 Nov 29:271:122885. Animal Diseases. 02 November 2021. Arch Pharm Res. 2024 Dec 10. bioRxiv. 2024 Feb 9. Nat Commun. 2022 Mar 2;13(1):1116. [1]Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58(6):1657-63. [2]Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02434-16. [3]Hamblin KA, et, al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. [4]LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153(9):e181804.
Smiles	[H]Cl.O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Bay-09867 (monohydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Apoptosis; Bacterial; Mitochondrial Metabolism; Reactive Oxygen Species; Topoisomerase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	367.808
Product Description	Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].
Manufacturer - Research Area	Infection; Cancer
Solubility	DMSO : 5 mg/mL (ultrasonic)\|H2O : 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Isoform	Quinolone
Clinical information	Launched

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HY-B0356A-1g-safety-datasheet.pdf