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Probucol

Probucol

Item no.	HY-B0388-100mg
Manufacturer	MedChem Express
CASRN	23288-49-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Neuroscience Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Cardiovascular Research Ischemia & Reperfusion Injury Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]1.A Unique Antilipidemic Drug - Probucol". Journal of Atherosclerosis and Thrombosis. 15 (6): 304–5. \|[2]2.Steinberg D. Studies on the mechanism of action of probucol. Am J Cardiol. 1986 Jun 27;57(16):16H-21H.\|[3]3.Favari E, et al. Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2345-50. \|[4]4.Zhong JK, et al. Probucol alleviates atherosclerosis and improves high density lipoprotein function. Lipids Health Dis. 2011 Nov 12;10:210. \|[5]5.Zhou X, et al. Probucol promotes high glucose-induced proliferation and inhibits apoptosis by reducing reactive oxygen species generation in Müller cells. Int Ophthalmol. 2019 Dec;39(12):2833-2842.\|[6]6.Iqbal M, et al. Probucol as a potent inhibitor of oxygen radical-induced lipid peroxidation and DNA damage: in vitro studies. Redox Rep. 2004;9(3):167-72. \|[7]7.Santos DB, et al. Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1. Mol Neurobiol. 2020 Aug;57(8):3245-3257. \|[8]8.Siveski-Iliskovic, et al. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation. 1994 Jun;89(6):2829-35. \|[9]9.Siveski-Iliskovic, et al. Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation. 1995 Jan 1;91(1):10-5. \|[10]10.Wang H, et al. Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Res Ther. 2020 Jul 21;11(1):302. \|[11]11.Tao ZS, et al. Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress. Mol Med. 2022 Jun 28;28(1):75. \|[12]12.Sia YT, et al. Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation. 2002 May 28;105(21):2549-55.\|[13]13.Zhang W, et al. Probucol recovers pathological damage in viral Myocarditis through improvement of myocardium-related proteins. Microb Pathog. 2020 Oct;147:104257.
Smiles	CC(SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	DH-581
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Apoptosis; Caspase; Glutathione Peroxidase; Reactive Oxygen Species (ROS); Virus Protease
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	516.84
Product Description	Probucol (DH-581) is an anti-hyperlipidemic agent. Probucol activates glutathione peroxidase. Probucol promotes low density lipoprotein (LDL) catabolism, inhibits ABCA1-dependent cholesterol efflux, and decreases HDL-C levels. Probucol also has anti-inflammatory, antioxidant and neuroprotective properties. Probucol can be used for researches on bone, cardiovascular, cancer, neurological, and metabolism-related diseases[1][2][3][4][5][6][7][8][9][10][11][12][13].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 125 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Isoform	Caspase 3; Caspase 9
Clinical information	Launched

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HY-B0388-100mg-safety-datasheet.pdf