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Hydralazine (hydrochloride)

Hydralazine (hydrochloride)

Item no.	HY-B0464-100mg
Manufacturer	MedChem Express
CASRN	304-20-1
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Fang C C, et al. Hydralazine inhibits human peritoneal mesothelial cell proliferation and collagen synthesis [J]. Nephrology Dialysis Transplantation, 1996, 11(11): 2276-2281.\|[2]Kalkhoran S B, et al. Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission [J]. Cardiovascular Research, 2022, 118(1): 282-294.\|[3]Ruiz-Magaña M J, et al. The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells [J]. Oncotarget, 2016, 7(16): 21875.\|[4]Quan X, et al. Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury [J]. Experimental Neurology, 2023, 363: 114367.\|[5]Rodrigues S F, et al. Hydralazine reduces leukocyte migration through different mechanisms in spontaneously hypertensive and normotensive rats [J]. European journal of pharmacology, 2008, 589(1-3): 206-214. Neurosci Bull. 2020 Oct;36(10):1158-1170.\|J Pharm Anal. 2023 Aug 11.
Smiles	NNC1=NN=CC2=C1C=CC=C2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	304-20-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Bcl-2 Family; Caspase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	196.64
Product Description	Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility	H2O: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Isoform	Bcl-2; Bcl-xL; Caspase 3; Caspase 8; Caspase 9
Clinical information	Launched

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HY-B0464-100mg-safety-datasheet.pdf