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Isoprenaline (hydrochloride)

Isoprenaline (hydrochloride)

Item no.	HY-B0468-1g
Manufacturer	MedChem Express
CASRN	51-30-9
Amount	1 g
Quantity options	100 mg 10 mM/1 mL 1 g 200 mg 5 g
Category	Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-K<sub>m</sub> cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7\|[2]Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30.\|[3]Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8.\|[4]Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700.\|[5]Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35.\|[6]M E Conolly, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol ACS Appl Mater Interfaces. 2023 Mar 29.\|ACS Appl Mater Interfaces. 2023 Oct 4.\|ACS Nano. 2023 Oct 18.\|Biochem Biophys Res Commun. 7 January 2022.\|Biochem Pharmacol. 2024 May 29:116329.\|Biochim Biophys Acta Mol Basis Dis. 2024 Jan 5:167018.\|Biofabrication. 2022 Oct 4.\|Biomed Pharmacother. 2021 Apr 8;139:111562.\|Biomed Pharmacother. 2021, 111531.\|Biomolecules. 2022, 12(11), 1574.\|bioRxiv. 2020 Jan.\|bioRxiv. 2024 Apr 20.\|Cell Biol Int. 2021 Jan;45(1):188-197.\|Cell Cycle. 2021 Jun 7;1-17.\|Cell Death Differ. 2022 Nov 3.\|Cell Mol Immunol. 2023 Jan 5.\|Cell Rep. 2022 Mar 8;38(10):110468.\|Cell Rep. 2019 Dec 3;29(10):2929-2935.e4\|Chem Biol Drug Des. 2024 Feb 6.\|Chem Eng J. 2024 Sep 1.\|Chin Med. 2024 Jun 11;19(1):82.\|Circulation. 2018 Jun 5;137(23):2497-2513.\|Eur J Pharmacol. 2020 Nov 5;886:173439.\|Eur J Pharmacol. 2021 Jun 23;907:174277.\|Eur J Pharmacol. 2024 Oct 30:177085.\|FASEB J. 2022 Mar;36(3):e22219.\|Food Chem Toxicol. 2023 Feb 17;113670.\|Food Funct. 2018 Nov 14;9(11):5528-5535. \|Front Oncol. 2021 Apr 22;11:665763.\|Int Immunopharmacol. 2023 Sep 5;124(Pt A):110876.\|Int J Exp Pathol. 2025 Mar;106(2):e12526.\|iScience. 2023 Jul 19.\|J Adv Res. 2024 Dec 28.\|J Cardiovasc Transl Res. 2023 Jan 30.\|J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. \|J Funct Foods. 66 (2020) 1038022.\|J Mol Cell Cardiol Plus. 2024 Dec.\|J Pharm Anal. 2024 Jan 4.\|J Tradit Complement Med. 2023 Jul 12.\|Mbio. 2022 Nov 29;e0229722.\|Molecules. 2024 Feb 7;29(4):760.\|Nat Commun. 2020 Sep 25;11(1):4857.\|Nat Prod Commun. 2023, 18(1): 1934578X221144581.\|Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1373-1385. \|Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 17.\|Pharmaceuticals. 2022, 15(1), 73.\|Prostate. 2020 Nov;80(15):1328-1340.\|Redox Biol. 2024 Dec 21:79:103481.\|Res Sq. 2024 Sep 30.\|Research Square Preprint. 2021 Jan.\|Research Square Preprint. 2023 Sep 14.\|Research Square Print. 2023 Feb 7.\|Sci Rep. 2024 Jul 8;14(1):15683.\|Science. 2020 Dec 4;370(6521):eaay2002.\|Biomed Res-TOKYO. 2023 Jun 1.\|Inflammation. 2024 Mar 6.\|J Inflamm Res. 2023 Oct 24.\|Nutrients. 2023 Mar 9.
Smiles	OC1=CC=C(C(O)CNC(C)C)C=C1O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Isoproterenol (hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	247.72
Product Description	Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology
Solubility	DMSO: 80 mg/mL (ultrasonic)\|H2O: ≥ 50 mg/mL
Manufacturer - Pathway	GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	β adrenergic receptor
Clinical information	Launched

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HY-B0468-1g-safety-datasheet.pdf