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Paroxetine (hydrochloride)

Paroxetine (hydrochloride)

Item no.	HY-B0492-500mg
Manufacturer	MedChem Express
CASRN	78246-49-8
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Signaling Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Wang Q, et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28;7:45364.\|[2]Lassen TR, et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112(3):26.\|[3]Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.\|[4]Liu RP, et al. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation. 2014 Mar 12;11:47.\|[5]Zarei M, et al. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J. 2014;18(2):94-100. Autophagy. 2024 Dec 11.\|Brain Res. 2019 Oct 1;1720:146296. \|Cell. 2021 Apr 15;184(8):2167-2182.e22.\|Front Pharmacol. 2024 Jul 31:15:1389761.\|J Chem Inf Model. 2021 Jul 21.\|J Mol Cell Cardiol Plus. 2024 Jun, 8, 100072.\|Biochem Biophys Res Commun. 2024 Jun 13:725:150263.\|Front Pharmacol. 22 June 2022.
Smiles	FC1=CC=C([C@H]2[C@H](COC3=CC=C(OCO4)C4=C3)CNCC2)C=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BRL29060 (hydrochloride),BRL29060A
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; G Protein-coupled Receptor Kinase (GRK); Serotonin Transporter
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	365.83
Product Description	Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 5 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling
Isoform	GRK2
Clinical information	Launched

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HY-B0492-500mg-safety-datasheet.pdf