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Desloratadine

Desloratadine

Item no.	HY-B0539-10mM
Manufacturer	MedChem Express
CASRN	100643-71-8
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 1 g 250 mg 25 mg 500 mg 50 mg
Category	Food Safety Histamines Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.98
Formula	C19H19ClN2
Citations	[1]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62. [2]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77. [3]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37. [4]McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797. [5]Agrawal, et al. "Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug." Expert opinion on investigational drugs 10.3 (2001): 547-560. [6]Kowalski, et al. "Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine." Allergy 60.1 (2005): 80-85.
Smiles	ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Sch34117
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Histamine Receptor; Leukotriene Receptor; TNF Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	310.828
Product Description	Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria[1][2][3][4][5][6].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : < 0.1 mg/mL
Manufacturer - Pathway	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H1 Receptor; Human Endogenous Metabolite
Clinical information	Launched

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HY-B0539-10mM-safety-datasheet.pdf