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Propranolol (hydrochloride)

Propranolol (hydrochloride)

Item no.	HY-B0573-1g
Manufacturer	MedChem Express
CASRN	318-98-9
Amount	1 g
Quantity options	100 mg 10 mM/1 mL 1 g 500 mg
Category	Metabolism Diabetes Glucose Homeostasis Cardiovascular Research Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1\|[2]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.\|[3]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.\|[4]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. Behav Brain Res. 28 October 2021, 113642.\|Biochem Biophys Res Commun. 2023 Mar 21;657:69-79.\|bioRxiv. 2024 November 03.\|BMC Pulm Med. 2021 Jun 5;21(1):189.\|Cell Metab. 2024 Mar 5;36(3):466-483.e7.\|Cell. 2025 Jan 9;188(1):157-174.e22.\|Chemosphere. 2019 Jun;225:378-387. \|Elife. 2024 May 29.\|J Endocrinol. 2020 Mar;244(3):459-471.\|Psychopharmacology. 2023 Jun 17.\|Acta Pharm Sin B. 2024 Apr 23.\|Am J Pathol. 2023 Apr 21;S0002-9440(23)00132-3.\|Bone Res. 2024 Mar 21;12(1):18.\|Environ Toxicol. 2023 Dec 2.\|Exp Neurol. 2023 Apr 19;114418.\|Food Chem Toxicol. 2024 Sep 6:114983.\|iScience. 2023 Jul 19.\|J Chromatogr B. 2023 Jun 20, 123804.\|J Immunother Cancer. 2024 Dec 9;12(12):e009910.\|J Pharmaceut Biomed. 2020, 113870.\|Nat Commun. 2023 May 2;14(1):2523.\|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.\|Pharmacol Res Perspect. 2021 Oct;9(5):e00879.\|Phytomedicine. 2024 Aug 19:134:155970.\|Redox Biol. 2024 Dec 21:79:103481.\|Research Square Print. December 21st, 2022.\|Sci Signal. 2020 Nov 24;13(659):eaax0273.
Smiles	OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	318-98-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Adrenergic Receptor; Bacterial
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	295.80
Product Description	Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
Manufacturer - Research Area	Neurological Disease; Endocrinology; Cancer; Cardiovascular Disease
Solubility	DMSO: ≥ 150 mg/mL\|H2O: 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Neuronal Signaling
Isoform	β adrenergic receptor
Clinical information	Launched

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HY-B0573-1g-safety-datasheet.pdf