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S-Adenosyl-L-methionine

S-Adenosyl-L-methionine

Item no.	HY-B0617-10mM
Manufacturer	MedChem Express
CASRN	29908-03-0
Amount	10 mMx1 mL
Quantity options	1 ea 100 mg 10 mMx1 mL 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.55
Citations	[1]G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.\|[2]Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.\|[3]Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.\|[4]Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. \|[5]Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. \|[6]Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. \|[7]Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. Biochem Pharmacol. 2023 Dec 6:219:115967.\|bioRxiv. 2023 Jun 1.\|Epigenetics Chromatin. 2021 Dec 4;14(1):52.\|Int Immunopharmacol. 2021 Mar 22;95:107545.\|J Agric Food Chem. 2021 Jul 30.\|Research Square Preprint. 2020 Aug.\|Research Square Preprint. 2021 Jun.\|Environ Sci Technol. 2025 Jan 2.\|Nat Commun. 2024 Nov 12;15(1):9529.\|J Cell Physiol. 2024 Oct 6:e31452.\|Molecules. 2023 Apr 11, 28(8), 3375.\|J Pharm Biomed Anal. 2024 Jan 20, 115991.\|Pharmacol Res. 2024 Sep 16:107420.
Smiles	O[C@H]1[C@](O[C@@H]([C@H]1O)C[S+](C)CC[C@H](N)C([O-])=O)([H])N2C3=NC=NC(N)=C3N=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	S-Adenosyl methionine,Ademetionine,AdoMet
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Apoptosis; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	398.44
Product Description	S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 43 mg/mL
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0617-10mM-safety-datasheet.pdf