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Epinastine

Epinastine

Item no.	HY-B0640-10mM
Manufacturer	MedChem Express
CASRN	80012-43-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 500 mg 50 mg
Category	Oncology Food Safety Histamines Neuroscience Neuroinflammation Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]C Kamei, et al. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol. 1992;14(1-2):191-205.\|[2]T Roeder, et al. Epinastine, a highly specific antagonist of insect neuronal octopamine receptors. ur J Pharmacol. 1998 May 22;349(2-3):171-7. \|[3]T Kohyama, et al. A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochem Biophys Res Commun. 1997 Jan 3;230(1):125-8.\|[4]Nakagawa T, et al. Modulatory effects of epinastine hydrochloride on IL-4 mRNA expression by peripheral blood mononuclear cells. Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):321-2. \|[5]Hanashiro K, et al. Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells. Eur J Pharmacol. 2006 Oct 10;547(1-3):174-83. \|[6]Kanai K, et al. Suppressive activity of epinastine hydrochloride on TARC production from human peripheral blood CD4+ T cells in-vitro. J Pharm Pharmacol. 2005 Aug;57(8):1027-36. \|[7]Inagaki N, et al. Evaluation of anti-scratch properties of oxatomide and epinastine in mice. Eur J Pharmacol. 2000 Jul 14;400(1):73-9. \|[8]Zhang X, et al. Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy. BMC Biol. 2025 Jan 27;23(1):27.
Smiles	NC1=NCC2N1C3=CC=CC=C3CC4=CC=CC=C24
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	WAL801
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Histamine Receptor; Interleukin Related; Transmembrane Glycoprotein
Manufacturer - HS Code	H302, H319, H372, H410
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	249317
Product Description	Epinastine (WAL801) is a selective and orally active histamine H1 receptor antagonist, CD96/PVR inhibitor and mast cell stabilizer. Epinastine has high affinity for neuronal octopamine receptors in locusts (Ki = 2 nM) and honeybees (Ki = 1.1 nM). Epinastine hydrochloride inhibits TARC, IL-8, and IL-4. Epinastine activates anti-colon cancer immunity and inhibits Substance P (HY-P0201)-induced scratching behavior and increased vascular permeability. Epinastine can be used in the research of allergic diseases[1][2][3][4][5][6][7][8].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility	DMSO : ≥ 50 mg/mL\|H2O : < 0.1 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Clinical information	Launched
Isoform	H1 Receptor; IL-4; IL-8
UNSPSC Code	12352005
Precautionary	H302, H319, H372, H410

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