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Hematoporphyrin

Hematoporphyrin

Item no.	HY-B0754-10mM
Manufacturer	MedChem Express
CASRN	14459-29-1
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.\|[2]Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.\|[3]Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22(1):49-53. Chem Eng J. 390 (2020) 124521.\|Drug Deliv. 2022 Dec;29(1):3358-3369.\|FEBS Lett. 2021 Jan;595(2):206-219.\|Int J Mol Sci. 2022 Apr 11;23(8):4218.\|J Biol Chem. 2022 Aug 26;102417.\|Lasers Med Sci. 2020 Feb;35(1):71-78.\|Nat Biomed Eng. 2022 Dec 22.\|Nat Commun. 2022 Jun 16;13(1):3468.\|PLoS One. 2019 Sep 25;14(9):e0222331.\|ACS Nano. 2023 Nov 21.\|Acta Biomater. 2025 Jan 7:S1742-7061(25)00004-2.\|Cancer Adv. 2024;7:e24021.\|Free Radic Biol Med. 2023 Jul 25;207:239-246.\|Nanyang Technological University. 2024.\|Pharmaceutics. 2023 Aug 3, 15(8), 2076.
Smiles	O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(C(O)C)C4=C\C5=N/C(C(C(O)C)=C5C)=C\C(N2)=C1C)=N/3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Hematoporphyrin IX
Shipping Condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Apoptosis; Endogenous Metabolite
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light)
Molecular Weight	598.69
Product Description	Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 150 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	Phase 1

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HY-B0754-10mM-safety-datasheet.pdf