« Back
Home /
Bucladesine (sodium)

Bucladesine (sodium)

Item no.	HY-B0764-50mg
Manufacturer	MedChem Express
CASRN	16980-89-5
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 1 g 500 mg 50 mg 5 g
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.48
Citations	[1]Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20.\|[2]Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.\|[3]Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.\|[4]Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419.\|[5]Shimojo M, et al. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem. 1998 Sep;71(3):1118-26. Adv Sci (Weinh). 2021 Oct 31;e2100808.\|bioRxiv. 2024 Mar 31.\|Cell Commun Signal. 2022 Apr 12;20(1):52.\|Cell Stem Cell. 2021 Aug 5;28(8):1362-1379.e7.\|Cell Tissue Res. 2022 Feb 11.\|Cells. 2024 Jul 26;13(15):1260.\|Ecotoxicol Environ Saf. 2022 Aug 17;243:113982.\|Eur J Pharmacol. 2022 Aug 28;932:175231.\|FASEB J. 2020 Oct;34(10):13376-13395.\|FASEB J. 2024 May 15;38(9):e23622.\|FEBS Lett. 2021 Oct 23.\|Front Microbiol. 2021 Aug 17;12:692693.\|Genomics. 2025 Jan 21;117(2):111002.\|Int J Biol Sci. 2024 Aug 19;20(11):4476-4495.\|Int J Mol Sci. 2022, 23(20), 12595.\|Int J Mol Sci. 2023 Feb 8;24(4):3398.\|Int J Mol Sci. 2023 Mar 7.\|J Assist Reprod Genet. 2024 Mar 25.\|J Bone Miner Metab. 2021 Apr 8.\|J Endocrinol. 2019 Sep 1;JOE-19-0284.R2.\|J Steroid Biochem Mol Biol. 24 September 2022, 106192.\|Pigment Cell Melanoma Res. 2023 Aug 9.\|Plants. 2023 Oct 24, 12(21), 3666.\|Proteome Sci. 2023 Oct 11;21(1):16.\|protocols.io. 2024 Jan 12.\|Reproduction. 2021 May 27;162(1):33-45.\|Res Sq. 2024 Jun 11.\|SSRN. 2025 Jan 27.\|Toxicology. 2025 Jan 29:154069.\|Toxins. 2021 Aug 22;13(8):585.\|Exp Ther Med. January 31, 2022.\|Front Endocrinol. 2025 Feb 19:16:1570284.
Smiles	O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Dibutyryl cAMP (sodium salt),DBcAMP (sodium salt)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Phosphodiesterase (PDE); PKA
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	491.37
Product Description	Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing[1][2][3][4].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 100 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Isoform	PKA
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-B0764-50mg-safety-datasheet.pdf