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Promethazine (hydrochloride)

Promethazine (hydrochloride)

Item no.	HY-B0781-10mM
Manufacturer	MedChem Express
CASRN	58-33-3
Amount	10 mMx1 mL
Quantity options	10 mMx1 mL 1 g 500 mg 5 g
Category	Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.85
Citations	[1]Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56.\|[2]Kasai T, et al. Promethazine Hydrochloride Inhibits Ectopic Fat Cell Formation in Skeletal Muscle. Am J Pathol. 2017 Dec;187(12):2627-2634.\|[3]McDonough JA, et al. Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication. J Microencapsul. 2007 Mar;24(2):109-16. \|[4]Wink CS, et al. Effects of promethazine HCl on osteoporotic femora of adult castrated male rats. Acta Anat (Basel).
Smiles	CC(N(C)C)CN1C(C=CC=C2)=C2SC3=CC=CC=C13.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Adrenergic Receptor; Histamine Receptor; mAChR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	320.88
Product Description	Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors[1][2].
Manufacturer - Research Area	Neurological Disease; Endocrinology
Solubility	DMSO: 50 mg/mL (ultrasonic)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	5-HT2 Receptor; H1 Receptor
Clinical information	Launched

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HY-B0781-10mM-safety-datasheet.pdf