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LY2409881

LY2409881

Item no.	HY-B0788-5mg
Manufacturer	MedChem Express
CASRN	946518-61-2
Amount	5 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Citations	[1]Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45. Int J Mol Sci. 2023, 24(1), 320.\|Cell Rep. 2024 Oct 8;43(10):114827.\|Clin Transl Med. 2022 Jun;12(6):e850.
Smiles	O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	946518-61-2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	IKK
Shipping Temperature	Room temperature
Molecular Weight	485.04
Product Description	LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 37 mg/mL
Manufacturer - Pathway	NF-κB
Isoform	IKK-β
Clinical information	No Development Reported

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HY-B0788-5mg-safety-datasheet.pdf