AZ7550

Item no.	HY-B0794-5mg
Manufacturer	MedChem Express
CASRN	1421373-99-0
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67. Biopharm Drug Dispos. 2023 Jan 17.\|J Pharm Biomed Anal. 2025 Jan 3:255:116662.\|bioRxiv. 2024 Jul 2:2024.06.27.600680.
Smiles	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1421373-99-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Drug Metabolite; EGFR; IGF-1R
Shipping Temperature	Room temperature
Molecular Weight	485.58
Product Description	AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
Manufacturer - Research Area	Cancer; Endocrinology
Solubility	10 mM in DMSO
Manufacturer - Pathway	JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Clinical information	Phase 1

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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