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Econazole

Econazole

Item no.	HY-B0885-100mg
Manufacturer	MedChem Express
CASRN	27220-47-9
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Mason MJ, et al. Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365. Am J Physiol. 1993 Mar;264(3 Pt 1):C654-62.\|[2]Heel RC, et al. Econazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1978 Sep;16(3):177-201.\|[3]Hill K, et al. Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):227-37.\|[4]Köfeler HC, et al. Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. Br J Pharmacol. 2000 Jul;130(6):1241-6.\|[5]Liu CF, et al. Antioxidative natural product protect against econazole-induced liver injuries. Toxicology. 2004 Mar 1;196(1-2):87-93. Adv Sci (Weinh). 2024 Jul 23:e2310126.\|Oxid Med Cell Longev. 2019 Aug 5;2019:8265958. \|Anal Biochem. 2019 Dec 15;587:113463.
Smiles	ClC1=CC=C(C(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(±)-Econazol
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Bacterial; Calcium Channel; Cytochrome P450; Fungal
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	381.68
Product Description	Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage[1][2][3][4][5].
Manufacturer - Research Area	Infection; Metabolic Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Clinical information	Launched

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HY-B0885-100mg-safety-datasheet.pdf