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Benzethonium (chloride)

Benzethonium (chloride)

Item no.	HY-B0942-100mg
Manufacturer	MedChem Express
CASRN	121-54-0
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.47
Citations	[1]Maillard JY. Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance. J Appl Microbiol. 2022 Dec;133(6):3322-3346.\|[2]Yip KW, et al. Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen. Clin Cancer Res. 2006 Sep 15;12(18):5557-69. \|[3]Sreevidya VS, et al. Benzalkonium chloride, benzethonium chloride, and chloroxylenol - Three replacement antimicrobials are more toxic than triclosan and triclocarban in two model organisms. Environ Pollut. 2018 Apr;235:814-824.
Smiles	CC(C)(C)CC(C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1)(C)C.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	121-54-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Apoptosis; Bacterial; Caspase; nAChR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	448.08
Product Description	Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes, which has antibacterial, anticancer, antisepsis and disinfection activity. Benzethonium chloride induced Apoptosis and activated caspases in cancer cell lines. Benzethonium chloride ablates the tumor-forming ability of FaDu cells, delays the growth of xenograft tumors in vivo[1][2][3].
Manufacturer - Research Area	Cancer; Infection; Neurological Disease
Solubility	DMSO: 33.33 mg/mL (ultrasonic)\|H2O: 20 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

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HY-B0942-100mg-safety-datasheet.pdf