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Aminoguanidine (hydrochloride)

Aminoguanidine (hydrochloride)

Item no.	HY-B1041-100mg
Manufacturer	MedChem Express
CASRN	1937-19-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 25 mg 500 mg 50 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394(1-2):129-35.\|[2]Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47(5):572-580. PMID: 29066484.\|[3]Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66(3):265-70.\|[4]Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16(1):8-14. Biomed Pharmacother. 2019 Dec;120:109527.\|Biomed Pharmacother. 2022 May 17;151:113109.\|Microb Pathog. 2024 Oct 20:197:107046.\|SSRN. 2024 May 22.\|Skelet Muscle. 2025 Jan 13;15(1):2.
Smiles	NNC(N)=N.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Pimagedine hydrochloride,GER-11,Aminoguanidinium chloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Apoptosis; NO Synthase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	110.55
Product Description	Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research[1][2][3][4].
Manufacturer - Research Area	Endocrinology
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 100 mg/mL
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation
Clinical information	Phase 1

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HY-B1041-100mg-safety-datasheet.pdf