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Tiratricol

Tiratricol

Item no.	HY-B1201-10mM
Manufacturer	MedChem Express
CASRN	51-24-1
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 50 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Type	Inhibitors
Specific against	other
Purity	99.60
Citations	[1]Ren H, et al. Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5. Antiviral Res. 2023 Nov;219:105737.\|[2]Cascales L, et al. Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell. Chem Biol Drug Des. 2008 Oct;72(4):320-8.
Smiles	O=C(O)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	3,3',5-Triiodothyroacetic acid
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Flavivirus; Thyroid Hormone Receptor; TNF Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	621.93
Product Description	Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication.[2].
Manufacturer - Research Area	Endocrinology
Solubility	DMSO: ≥ 42 mg/mL
Manufacturer - Pathway	Anti-infection; Apoptosis; Vitamin D Related/Nuclear Receptor
Clinical information	Launched

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HY-B1201-10mM-safety-datasheet.pdf