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Chlormethine (hydrochloride)

Chlormethine (hydrochloride)

Item no.	HY-B1253-10mM
Manufacturer	MedChem Express
CASRN	55-86-7
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg
Category	Oncology Food Safety Allergenes Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.0
Formula	C5H12Cl3N
Citations	[1]Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577. [2]Yuan Yang, et al. Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. Kidney Blood Press Res. 2018;43(1):68-79. [3]Liren Tang, et al. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol. 2003 Mar;120(3):400-6. [4]K Bryniarski, et al. The in vivo and in vitro effects of an alkylating agent, mechlorethamine, on IL-6 production in mice and the role of macrophages. Immunopharmacology. 1996 Sep;34(2-3):73-8.
Smiles	ClCCN(CCCl)C.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Mechlorethamine hydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Biochemical Assay Reagents
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	192.51
Product Description	Chlormethine hydrochloride is a foaming agent that causes necrotic and irritating damage to mucous membranes. Used as an antitumor agent in Hodgkin's disease and lymphoma.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Others
Clinical information	Launched

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HY-B1253-10mM-safety-datasheet.pdf