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Nylidrin (hydrochloride)

Nylidrin (hydrochloride)

Item no.	HY-B1404-200mg
Manufacturer	MedChem Express
CASRN	849-55-8
Amount	200 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	98.66
Citations	[1]A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4)\|[2]Boiteau GM, et al. Nylidrin HCl: a beta-sympathetic stimulant in the management of haemorrhagic shock. Can Anaesth Soc J. 1966 May;13(3):252-62.\|[3]Niemeyer G, et al. Effects of buphenine (nylidrin) on the perfused mammalian eye. Graefes Arch Clin Exp Ophthalmol. 1987;225(1):33-8.\|[4]Whittemore ER, et al. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337(2-3):197-208.\|[5]Jang Y, et al. In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus. Viruses. 2020 May 25;12(5):581.
Smiles	OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Buphenine hydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Histamine Receptor
Manufacturer - HS Code	H302, H312, H332
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	335.87
Product Description	Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects[1][2][3][4][5].
Manufacturer - Research Area	Infection; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO : ≥ 41 mg/mL\|H2O : 5 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H302, H312, H332

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