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Serotonin (hydrochloride)

Serotonin (hydrochloride)

Item no.	HY-B1473-10mM
Manufacturer	MedChem Express
CASRN	153-98-0
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 250 mg 50 mg
Category	Neuroscience Neuroinflammation Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.\|[2]Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774. Authorea. September 19, 2022.\|bioRxiv. 2023 Oct 13.\|bioRxiv. 2024 November 03.\|J Immunother Cancer. 2021 Jul;9(7):e002383.\|Nature. 2024 Dec 18.\|Res Sq. 2024 Jun 11.\|Research Square Preprint. 2023 Dec 28.\|bioRxiv. 2024 November 03.\|Curr Res Food Sci. 2024 Apr 26:8:100754.\|Int J Mol Sci. 2022, 23(20), 12420.\|J Exp Clin Cancer Res. 2024 Oct 10;43(1):284.
Smiles	OC1=CC2=C(NC=C2CCN)C=C1.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5-Hydroxytryptamine (hydrochloride),5-HT (hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor; COMT; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	212.68
Product Description	Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 125 mg/mL (ultrasonic)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	Human Endogenous Metabolite; Microbial Metabolite; MUC4
Biological activity	Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 uM. IC50 & Target: 5-HT receptor^[1] Ki: 44 uM (COMT)^[1] In Vitro: Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K_i=?44 uM). Results show that addition of 100 uM of Serotonin hydrochloride decreases the reaction velocity of COMT^[1]. In Vivo: Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001)^[1]. A significant increase in colonic 5-HT content is observed in IL-13^-/- mice receiving Serotonin hydrochloride compare to IL-13^-/- receiving vehicle following induction of DSS colitis^[2].
Clinical information	Launched

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HY-B1473-10mM-safety-datasheet.pdf