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Imipramine (hydrochloride)

Imipramine (hydrochloride)

Item no.	HY-B1490-100mg
Manufacturer	MedChem Express
CASRN	113-52-0
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Signaling Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.92
Citations	[1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292.\|[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. \|[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. \|[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.\|[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. Cell Commun Signal. 2023 May 25;21(1):123.\|Inflammation. 2021 Jan 29.\|J Agric Food Chem. 2024 Jul 11.\|Pathogens. 2022 May 22;11(5):602.\|Int Immunopharmacol. 2025 Jan 6:147:113969.\|Nat Chem Biol. 2024 Feb 14.
Smiles	CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	113-52-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Apoptosis; Autophagy; Serotonin Transporter
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	316.87
Product Description	Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: ≥ 100 mg/mL\|H2O: 62.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Neuronal Signaling
Clinical information	Launched

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HY-B1490-100mg-safety-datasheet.pdf