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Fluazinam

Fluazinam

Item no.	HY-B1839-10mM
Manufacturer	MedChem Express
CASRN	79622-59-6
Amount	10 mM/1 mL
Quantity options	100 mg 10 g 10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.36
Citations	[1]Hou YP, et al. Impact of fluazinam on morphological and physiological characteristics of Sclerotinia sclerotiorum. Pestic Biochem Physiol. 2019 Mar;155:81-89.\|[2]Lee JE, et al. Fluazinam targets mitochondrial complex I to induce reactive oxygen species-dependent cytotoxicity in SH-SY5Y cells. Neurochem Int. 2012 Jun;60(8):773-81.\|[3]Chen YL, et al. Activity of the dinitroaniline fungicide fluazinam against Bipolaris maydis. Pestic Biochem Physiol. 2018 Jun;148:8-15.\|[4]Qu XP, et al. Effects of the dinitroaniline fungicide fluazinam on Fusarium fujikuroi and rice. Pestic Biochem Physiol. 2018 Nov;152:98-105.\|[5]Wang XH, et al. Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae. Chemosphere. 2018 Nov;210:633-644. \|[6]Wu W, et al. Acute toxicity of fluazinam to aquatic organisms and its bioaccumulation in Brachydanio rerio. Environ Sci Pollut Res Int. 2020 Oct;27(28):35000-35007.\|[7]Gomes DS, et al. Acute exposure to fungicide fluazinam induces cell death in the midgut, oxidative stress and alters behavior of the stingless bee Partamona helleri (Hymenoptera: Apidae). Ecotoxicol Environ Saf. 2024 Sep 1;282:116677.
Smiles	FC(C1=CN=C(NC2=C([N+]([O-])=O)C=C(C(F)(F)F)C(Cl)=C2[N+]([O-])=O)C(Cl)=C1)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	79622-59-6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Apoptosis; Autophagy; Bcl-2 Family; Caspase; Fungal; JNK; p38 MAPK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	465.09
Product Description	Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees[1][2][3][4][5][6][7].
Manufacturer - Research Area	Infection
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; MAPK/ERK Pathway
Clinical information	No Development Reported

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HY-B1839-10mM-safety-datasheet.pdf