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Orotic acid

Orotic acid

Item no.	HY-N0157-100mg
Manufacturer	MedChem Express
CASRN	65-86-1
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Hepatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.\|[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15.\|[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21.
Smiles	O=C(C(NC1=O)=CC(N1)=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	6-Carboxyuracil,Vitamin B13
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Endogenous Metabolite; Nucleoside Antimetabolite/Analog
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	156.10
Product Description	Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : < 0.1 mg/mL
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Clinical information	Launched
Isoform	Human Endogenous Metabolite

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