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Catharanthine (Tartrate)

Catharanthine (Tartrate)

Item no.	HY-N0252A-10mg
Manufacturer	MedChem Express
CASRN	4168-17-6
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 20 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.88
Citations	[1]Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92.\|[2]Hugo R Arias, et al. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454.
Smiles	O=C([C@@]1(C2=C3C(C=CC=C4)=C4N2)[C@](C(CC)=C5)([H])[N@](CC3)C[C@]5([H])C1)OC.O[C@@H](C(O)=O)[C@H](C(O)=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(+)-3,4-Didehydrocoronaridine (Tartrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	486.51
Product Description	Catharanthine ((+)-3, 4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Tartrate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity[1][2].
Manufacturer - Research Area	Cancer; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 5 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 60°C)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	L-type calcium channel
Clinical information	No Development Reported

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HY-N0252A-10mg-safety-datasheet.pdf