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Coptisine

Coptisine

Item no.	HY-N0430-50mg
Manufacturer	MedChem Express
CASRN	3486-66-6
Amount	50 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Type	Inhibitors
Specific against	other
Citations	[1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.\|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.\|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565. DNA Cell Biol. 2020 Oct 2. \|J Oncol. 26 Jun 2022.\|SSRN. 2024 Apr 1.\|Int Immunopharmacol. 2024 Jan 4:128:111433.\|Molecules. 2024 May 14.\|Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 19.\|Planta Med. 2024 Jun;90(7-08):523-533.
Smiles	C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Coptisin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Indoleamine 2, 3-Dioxygenase (IDO)
Shipping Temperature	Room temperature
Molecular Weight	320.32
Product Description	Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.
Manufacturer - Research Area	Cancer; Metabolic Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	IDO
Clinical information	No Development Reported

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