« Back
Home /
Dehydrocostus Lactone

Dehydrocostus Lactone

Item no.	HY-N0591-10mg
Manufacturer	MedChem Express
CASRN	477-43-0
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Eun Ji Kim, et al. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food and Chemical Toxicology Volume 46, Issue 12, December 2008, Pages 3651–3658\|[2]Nie Y, Wang Z, Chai G, et al. Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt. Molecules. 2019;24(8):1510. \|[3]Taniguchi M, et al. Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. Biosci Biotechnol Biochem. 1995 Nov;59(11):2064-7.\|[4]Cantrell CL, et al. Antimycobacterial activities of dehydrocostus lactone and its oxidation products. J Nat Prod. 1998 Oct;61(10):1181-6.
Smiles	O=C(O[C@@]([C@@]1([H])C(CC[C@@]21[H])=C)([H])[C@@]3([H])CCC2=C)C3=C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(-)-Dehydrocostus lactone,Epiligulyl oxide
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Akt; Apoptosis; Bacterial; Caspase; Interleukin Related; MAPKAPK2 (MK2); NF-κB; NO Synthase; p38 MAPK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	230.30
Product Description	Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO: 250 mg/mL (ultrasonic)\|Ethanol: 15 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-N0591-10mg-safety-datasheet.pdf