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Dehydrocorydaline (chloride)

Dehydrocorydaline (chloride)

Item no.	HY-N0674A-5mg
Manufacturer	MedChem Express
CASRN	10605-03-5
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.75
Citations	[1]Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36.\|[2]Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129\|[3]Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85.\|[4]Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. Aging (Albany NY). 2021 Oct 7;13(19):23133-23148.\|Aging. 2021 May 11;13(9):12780-12799.\|Biochem Biophys Res Commun. 2018 May 23;499(4):743-750. \|Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473. \|Biochem Pharmacol. 2024 Oct 11:116574.\|BMC Musculoskelet Disord. 2022 May 30;23(1):514.\|Bone Joint Res. 2023 Nov 1;12(11):677-690.\|Comput Math Methods Med. 2021 Aug 2;2021:3337514.\|Eur J Histochem. 2025 Jan 21;69(1).\|Eur J Pharmacol. 2021 Mar 31;174069.\|Infect Genet Evol. 2021 Nov 23;105158.\|J Agric Food Chem. 2023 Oct 12.\|J Cell Physiol. 2019 Dec;234(12):22463-22476.\|J Clin Neurosci. 2020 Aug;78:365-370.\|J Mol Histol. 2021 Feb 8.\|J Nutr. 2020 Jul 1;150(7):1731-1737.\|Mol Carcinog. 2024 Aug 13.\|Biochem Pharmacol. 2025 Feb 19:116820.\|Bioengineered. 2022 May;13(5):12847-12862.\|Exp Eye Res. 2022 Dec 25;109365.\|Front Pharmacol. 31 May 2021.\|Int Immunopharmacol. 2024 Jul 23:139:112720.\|J Cardiothorac Surg. 2024 Dec 20;19(1):665.\|J Clin Invest. 2024 Jun 18:e178303.\|J Ethnopharmacol. 2024 Aug 31:118738.\|J Inflamm Res. 2021 Sep 16;14:4669-4686.\|New Phytol. 2024 May 13.\|Phytomedicine. 8 September 2021, 153740.\|Tissue Cell. 2023 Sep 11, 102218.\|Int J Biol Macromol. 2024 May;266(Pt 1):130939.\|Research Square Preprint. 2020 Dec.
Smiles	CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	13-Methylpalmatine (chloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy; Bcl-2 Family; Caspase; p38 MAPK; Parasite; PARP
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	401.88
Product Description	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway
Isoform	Plasmodium
Clinical information	No Development Reported

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HY-N0674A-5mg-safety-datasheet.pdf