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Rhoifolin

Rhoifolin

Item no.	HY-N0755-20mg
Manufacturer	MedChem Express
CASRN	17306-46-6
Amount	20 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 20 mg 5 mg
Category	Cell Biology Cytoskeleton Inhibitors & Compound Libraries Small Molecules small GTPases Rho Subfamily
Type	Inhibitors
Specific against	other
Purity	99.25
Citations	[1]Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from <i>Citrus grandis</i> (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375.\|[2]Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611.\|[3]Eldahshan. O. A, et al. Rhoifolin; A Potent Antiproliferative Effect on Cancer Cell Lines. Journal of Pharmaceutical Research International, 2012, 3(1), pp. 46-53.\|[4]Omama E. El-Shawi, et al. Protective Effect of Rhoifolin on Gamma Irradiation Induced Cardiac Dysfunctions in Albino Mice. Feb 15, 2014.
Smiles	O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]3O[C@@](O[C@@H](C)[C@H](O)[C@H]4O)([H])[C@@H]4O)=C5)C2=C5O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	17306-46-6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy; GLUT; Insulin Receptor; NF-κB; p38 MAPK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	578.52
Product Description	Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3].
Manufacturer - Research Area	Metabolic Disease; Endocrinology; Cancer
Solubility	DMSO: 62.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Protein Tyrosine Kinase/RTK
Isoform	GLUT4; NF-κB
Clinical information	No Development Reported

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HY-N0755-20mg-safety-datasheet.pdf