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Isorhynchophylline

Isorhynchophylline

Item no.	HY-N0766-10mg
Manufacturer	MedChem Express
CASRN	04.01.6859
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	99.82
Citations	[1]Wang K, et al. Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla. J Nat Prod. 2011 Jan 28;74(1):12-5. \|[2]Yuan D, et al. Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. J Nat Prod. 2008 Jul;71(7):1271-4. \|[3]Zhang F, et al. Effects of isorhynchophylline on angiotensin II-induced proliferation in rat vascular smooth muscle cells. J Pharm Pharmacol. 2008 Dec;60(12):1673-8. \|[4]Lee H, et al. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. Int J Mol Sci. 2017 May 19;18(5):1095. \|[5]Xian YF, et al. Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:163057. \|[6]Wu Y, et al. Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/β-catenin axis. Autoimmunity. 2023 Dec;56(1):2289868.\|[7]Jiang J, et al. Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes. J Orthop Surg Res. 2023 Mar 2;18(1):154.\|[8]Zhao H, et al. Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway. Neurochem Res. 2021 Aug;46(8):1981-1994. \|[9]Xian YF, et al. Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice. Neurochem Int. 2014 Oct;76:42-9.\|[10]Xian YF, et al. Antidepressant-Like Effect of Isorhynchophylline in Mice. Neurochem Res. 2017 Feb;42(2):678-685.\|[11]Li HQ, et al. Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in mice. Chin Med. 2018 Jun 14;13:29. \|[12]Qiu M, et al. Protective effects of isorhynchophylline against silicon-dioxide-induced lung injury in mice. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1125-1134.\|[13]Guo H, et al. Isorhynchophylline protects against pulmonary arterial hypertension and suppresses PASMCs proliferation. Biochem Biophys Res Commun. 2014 Jul 18;450(1):729-34.
Smiles	O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](CC)C4)([H])N4CC3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	04.01.6859
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	NF-κB; SOD
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	384.47
Product Description	Isorhynchophylline is an alkaloid isolated from Crocus sativus with anticancer, antihypertensive, anti-inflammatory, and neuroprotective properties. Isorhynchophylline can be applied to cardiovascular and neurological disorders, and cancer studies[1][2][3][4][5][6][7][8][9][10][11][12][13].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; NF-κB
Clinical information	No Development Reported

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HY-N0766-10mg-safety-datasheet.pdf