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Yangonin

Yangonin

Item no.	HY-N0919-10mg
Manufacturer	MedChem Express
CASRN	500-62-9
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	99.79
Citations	[1]Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB<sub>1</sub> receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.\|[2]Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.\|[3]Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.
Smiles	O=C1C=C(OC)C=C(/C=C/C2=CC=C(OC)C=C2)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	500-62-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Autophagy; Cannabinoid Receptor; NF-κB
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	258.27
Product Description	Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling; NF-κB
Isoform	CB1; RelA/p65
Clinical information	No Development Reported

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HY-N0919-10mg-safety-datasheet.pdf