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Cucurbitacin I

Cucurbitacin I

Item no.	HY-N1405-10mM
Manufacturer	MedChem Express
CASRN	03.07.2222
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 1 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Neural Transcription Factors Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	99.44
Formula	C30H42O7
Citations	[1]Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71. [2]Moon Hee Jeong, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10(8):e0136236.
Smiles	CC(C)(C1=CC[C@@]2([H])[C@@]3(C[C@@H](O)[C@@H]([C@]3(C4)C)[C@@](C)(O)C(/C=C/C(C)(O)C)=O)C)C(C(O)=C[C@@]1([H])[C@]2(C)C4=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Elatericin B; JSI-124; NSC-521777
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	JAK; STAT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	514.65
Product Description	Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Manufacturer - Pathway	Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Isoform	JAK2; STAT3
Clinical information	No Development Reported

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HY-N1405-10mM-safety-datasheet.pdf