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Phosphoramidon (disodium)

Phosphoramidon (disodium)

Item no.	HY-N2021A-10mg
Manufacturer	MedChem Express
CASRN	164204-38-0
Amount	10 mg
Quantity options	10 mMx1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Umezawa S, , et al. A new microbial metabolite phosphoramidon (isolation and structure). Tetrahedron Letters, 1972, 13(1): 97-100.\|[2]Suda H, et al. A thermolysin inhibitor produced by actinomycetes: phosphoramidon. The Journal of antibiotics, 1973, 26(10): 621-623.\|[3]Kukkola PJ, et al. Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.J CardiovascPharmacol. 1995;26Suppl 3:S65-8.\|[4]Matsumura Y, et al. Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1. Eur J Pharmacol. 1990 Aug 21;185(1):103-6.\|[5]McMahon EG, et al. Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):703-7.
Smiles	O=C([C@@H](NC([C@@H](NP(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](O1)C)(O[Na])=O)CC(C)C)=O)CC2=CNC3=CC=CC=C23)O[Na]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	164204-38-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Angiotensin-converting Enzyme (ACE); Endogenous Metabolite; MMP; Neprilysin
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	587.47
Product Description	Phosphoramidon disodium, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology; Cardiovascular Disease; Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 140 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	Microbial Metabolite
Clinical information	No Development Reported

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HY-N2021A-10mg-safety-datasheet.pdf