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24-Hydroxycholesterol

24-Hydroxycholesterol

Item no.	HY-N2370-2mg
Manufacturer	MedChem Express
CASRN	30271-38-6
Amount	2 mg
Quantity options	10 mM/1 mL 2 mg 5 mg
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules By Organ Pancreatic Cancer Nervous System Cancer
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Soncini M, et al. 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6219-E6227. Epub 2016 Sep 26.\|[2]Mast N, et al. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. 2017 Sep 1;123:465-476.
Smiles	CC(C)C(O)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	30271-38-6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	iGluR; LXR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	402.65
Product Description	24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 3.67 mg/mL (ultrasonic; warming; heat to 60°C)\|Ethanol: 60 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Isoform	NMDA Receptor
Clinical information	No Development Reported

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HY-N2370-2mg-safety-datasheet.pdf