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D-JNKI-1

D-JNKI-1

Item no.	HY-P0069-50mg
Manufacturer	MedChem Express
CASRN	1445179-97-4
Amount	50 mg
Quantity options	10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders By Cell Type Hematology Leukemia Lymphoma Mesothelioma Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.29
Citations	[1]Wang J, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci. 2003 Sep 17;23(24):8596-607.\|[2]Zhao Y, et al. The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Mol Cell Neurosci. 2012 Mar;49(3):300-10.\|[3]Kersting S, et al. The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium. J Inflamm Res. 2013 May 3;6:71-81.\|[4]Wang C, et al. Wu-tou decoction attenuates neuropathic pain via suppressing spinal astrocytic IL-1R1/TRAF6/JNK signaling. Oncotarget. 2017 Oct 6;8(54):92864-92879.
Smiles	O=C(N[C@H](CCC(N)=O)C(N[C@H](CO)C(N[C@H](CCCNC(N)=N)C(N1[C@H](CCC1)C(N[C@H](C(C)C)C(N[C@H](CCC(N)=O)C(N2[C@H](CCC2)C(N[C@H](CC3=CC=CC=C3)C(N[C@H](CC(C)C)C(N[C@H](CC(N)=O)C(N[C@H](CC(C)C)C(N[C@H]([C@@H](O)C)C(N[C@H]([C@@H](O)C)C(N4[C@H](CCC4)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N5[C@@H](C(N[C@H](CCCNC(N)=N)C(N6[C@H](CCC6)C(N7[C@H](CCC7)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC(O)=O)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AM-111,XG-102
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Targets	JNK
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	3822.44
Product Description	D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.
Manufacturer - Research Area	Others
Solubility	DMSO : ≥ 100 mg/mL\|H2O : ≥ 50 mg/mL
Manufacturer - Pathway	MAPK/ERK Pathway
Clinical information	Phase 3
Isoform	JNK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.