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SHU 9119

SHU 9119

Item no.	HY-P0227-1mg
Manufacturer	MedChem Express
CASRN	168482-23-3
Amount	1 mg
Quantity options	10 mMx1 mL 1 mg 5 mg
Category	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.95
Citations	[1]Grieco P, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 2007 Jun;28(6):1191-6.\|[2]Nogueiras R, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117(11):3475-88.\|[3]Kooijman S, et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55(10):2022-32.
Smiles	O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](CC(NCCCC[C@H](NC1=O)C(N)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]1CC5=CNC6=CC=CC=C56
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	168482-23-3
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Melanocortin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Molecular Weight	1074.24
Product Description	SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.
Manufacturer - Research Area	Metabolic Disease
Solubility	H2O: 10 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	MC3R; MC4R; MC5R
Clinical information	No Development Reported

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HY-P0227-1mg-safety-datasheet.pdf