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Colivelin

Colivelin

Item no.	HY-P1061-500ug
Manufacturer	MedChem Express
CASRN	867021-83-8
Amount	500 ug
Quantity options	100 mg 1 ea 1 mg 500 ug 5 mg
Category	Neuroscience Neural Lineage Markers Neural Transcription Factors Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.27
Formula	C119H206N32O35
Citations	Adv Rheumatol. 2024 Dec 18;64(1):88. Aging. 2020 May 15;12(10):9066-9084. Biochim Biophys Acta Mol Basis Dis. 2023 Dec 6:166979. BMC Neurosci. 2025 Mar 7;26(1):21. Cancer Immunol Immunother. 2022 Jun 20. Cell Signal. 2020 Jul;71:109606. CNS Neurosci Ther. 2023 Oct 23. Commun Biol. 2022 Dec 1;5(1):1316. Drug Dev Res. 2022 Oct 2. Ecotoxicol Environ Saf. 2024 Aug 12:283:116857. Free Radic Biol Med. 2024 Aug 28:S0891-5849(24)00630-0. Funct Integr Genomics. 2025 Mar 12;25(1):59. Inflammation. 2024 Jun 17. Int J Mol Sci. 2024 Mar 3, 25(5), 2950. Int J Nanomedicine. 2023 Nov 28. J Ethnopharmacol. 2024 Sep 13:118829. J Nanobiotechnology. 2024 Aug 24;22(1):509. J Nanobiotechnology. 2024 Jul 11;22(1):409. J Nat Med. 2020 Jun;74(3):533-544. J Physiol Sci. 2024 Feb 16. J Surg Res. 2025 Jan 13:306:249-256. Mol Biol Rep. 2024 Jan 22;51(1):176. Oncol Rep. 2024 May;51(5):71. Phytomedicine. 2024 Mar 22, 155563. Redox Biol. 2023 Nov 7, 102956. Sci Transl Med. 2021 Oct 6;13(614):eabg6428. SSRN. 2024 Apr 7. Tissue Cell. 2024 Nov 30:93:102645. World J Stem Cells. 2024 Nov 26;16(11):906-925. Ann Transl Med. 2020 Nov;8(21):1346. Antiviral Res. January 2022, 105228. Biochem Cell Biol. 2022 Nov 1. Biochem Cell Biol. 2022 Oct 20. Biomed Pharmacother. 2020 Nov;131:110541. Biomol Biomed. 2024 Aug 2. Brain Res Bull. 2024 Nov 13:219:111128. Cell Commun Signal. 2021 Nov 16;19(1):115. Drug Resist Updat. 2025 Feb 28. Exp Ther Med. March 1, 2022. Frigid Zone Medicine. 20 May 2022. Front Mol Biosci. 2021 Jun 18;8:654766. Inflamm Bowel Dis. 2023 Jun 19;izad099. Int Immunopharmacol. 2024 Apr 25:133:112126. Int Immunopharmacol. 2024 Oct 18;143(Pt 2):113416. Int J Biol Sci. 2023 Mar. Int J Neurosci. 2021 Jan;131(1):15-24. J Agric Food Chem. 2021 Jul 6. J Agric Food Chem. 2025 Feb 24. J Inflamm Res. 24 May 2022. J Nanobiotechnology. 2024 Jun 19;22(1):345. Mol Immunol. 2025 Mar 5:181:9-17. Nat Commun. 2021 Nov 25;12(1):6891. PeerJ. 2022 Sep 28;10:e14086. Phytomedicine. 2022: 154551. Phytomedicine. 2023 Apr 3, 154799. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2122099119. Research Square Preprint. 2020 Dec. SSRN. 2025 Jan 30. Vascul Pharmacol. 2024 Jul 17:107411. [1]Chiba T, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J Neurosci. 2005 Nov 2;25(44):10252-61. [2]Pan Z, et al. Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway.Cell Signal. 2020 Mar 18:109606. [3] Zhao H, et al. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.Neuroscience. 2019 Sep 15;416:198-206. [4]Fang YY, et al. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. Int J Neurosci. 2020 Mar 12:1-10. [5]Chiu WC, et al. The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways. PLoS One. 2016 Nov 22;11(11):e0166453.
Smiles	O=C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CCC1)C(N[C@@H](C)C(N2[C@@H](CCC2)C(N[C@@H](C)C(NCC(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	867021-83-8
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Amyloid-β; STAT
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	2645.10
Product Description	Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3?in vitro[1]. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease[2]. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury[1]
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 66.67 mg/mL (ultrasonic)
Manufacturer - Pathway	JAK/STAT Signaling; Neuronal Signaling; Stem Cell/Wnt
Isoform	STAT3
Clinical information	No Development Reported

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