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3-Deazaadenosine (hydrochloride)

3-Deazaadenosine (hydrochloride)

Item no.	HY-W013332A-1mg
Manufacturer	MedChem Express
CASRN	86583-19-9
Amount	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.67
Citations	[1]Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17.\|[2]Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8.\|[3]Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200. bioRxiv. 2024 May 18.\|Am J Physiol Cell Physiol. 2023 Dec 25.\|Arch Toxicol. 2021 Jan;95(1):299-309.\|BMC Biol. 2024 May 3;22(1):104.\|Cancer Cell Int. 2023 Dec 18;23(1):330.\|Cancer Res. 2021 Sep 15;81(18):4778-4793.\|Cell Biol Int. 2025 Mar 11.\|Cell Mol Biol Lett. 2024 Jul 3;29(1):97.\|Cell Rep. 2021 Jan 5;34(1):108580.\|Cell Signal. 2025 Jan 22:111623.\|Environ Pollut. 2023 May 9;121798.\|Eur J Pharmacol. 2024 Dec 31:177247.\|Exp Cell Res. 2024 Aug 27:114226.\|Genomics. 2022 Jul 4;110424.\|Int J Biol Sci. 2023; 19(2):593-609.\|J Cancer. 2023 Apr 17; 14(7): 1117-1131.\|J Neurosci. 2023 Jan 17;JN-RM-1209-22.\|Oncogene. 2024 Mar 5.\|Research Square Print. 2022 May.\|Transpl Immunol. 2024 Jul 10:102083.
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=C3)N=C2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	86583-19-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	HIV
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	302.72
Product Description	3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.
Manufacturer - Research Area	Infection; Inflammation/Immunology
Solubility	DMSO: 41.67 mg/mL (ultrasonic)\|H2O: ≥ 100 mg/mL
Manufacturer - Pathway	Anti-infection
Isoform	HIV-1
Clinical information	No Development Reported

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HY-W013332A-1mg-safety-datasheet.pdf