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(S)-(+)-Carvone

(S)-(+)-Carvone

Item no.	HY-W013579-100mg
Manufacturer	MedChem Express
CASRN	2244-16-8
Amount	100 mg
Quantity options	100 mg 1 g 500 mg 500 ul
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.43
Citations	[1]Jan Alexander, et al. Scientific Opinion on the safety assessment of carvone, considering all sources of exposure.European Food Safety Authority (EFSA), Parma, Italy.\|[2]Lv L, et al. d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells. J Biochem Mol Toxicol. 2021 May;35(5):e22746. \|[3]Wojtunik-Kulesza KA, et al. S-(+)-Carvone, a Monoterpene with Potential Anti-Neurodegenerative Activity-In Vitro, In Vivo and Ex Vivo Studies. Molecules. 2024 Sep 13;29(18):4365.\|[4]Iyappan P, et al. D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4). Bioinformation. 2021 Jan 31;17(1):171-180. \|[5]Sousa C, et al. Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line. Biomedicines. 2021 Jul 4;9(7):777.\|[6]Huchelmann A, et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. Plant Physiol. 2014 Feb;164(2):935-50. \|[7]Zhao M, et al. Anti-inflammatory and protective effects of D-carvone on lipopolysaccharide (LPS)-induced acute lung injury in mice. Journal of King Saud University-Science, 2020, 32(2): 1592-1596.\|[8]Dai M, et al. D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway. Biomed Pharmacother. 2020 Dec;132:110870.\|[9]Chen G, et al. Anti-arthritic activity of D-carvone against complete Freund's adjuvant-induced arthritis in rats through modulation of inflammatory cytokines. Korean J Physiol Pharmacol. 2020 Nov 1;24(6):453-462.\|[10]Nogoceke FP, et al. Antimanic-like effects of (R)-(-)-carvone and (S)-(+)-carvone in mice. Neurosci Lett. 2016 Apr 21;619:43-8.\|[11]Alsanea S, et al. BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. Pharm Res. 2017 Nov;34(11):2241-2249.\|[12]Gopalakrishnan T, et al. Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events. Biomed Pharmacother. 2019 Mar;111:178-187.
Smiles	C=C([C@H](C1)CC=C(C)C1=O)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	D-Carvone
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Apoptosis; Caspase; Interleukin Related; NOD-like Receptor (NLR); Reactive Oxygen Species (ROS); SOD
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	150.22
Product Description	(S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis[1][2][3][4][5][6][7][8][9][10][11][12].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Clinical information	No Development Reported

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HY-W013579-100mg-safety-datasheet.pdf