Urea

Item no.	HY-Y0271-100mg
Manufacturer	MedChem Express
CASRN	57-13-6
Amount	100 mg
Quantity options	100 mg 10mM/1mL 5 g
Category	Food Safety Other Parameters Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	CH4N2O
Citations	[1]Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7. [2]Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392. [3]Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29. [4]Michea L, et al., Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells. Am J Physiol Renal Physiol. 2000 Feb;278(2):F209-18. [5]Zhang Z, et al. High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9491-6. [6]Prabhakar SS, et al., Urea inhibits inducible nitric oxide synthase in macrophage cell line. Am J Physiol. 1997 Dec;273(6):C1882-8. [7]Yang XY, et al., ERK activation by urea in the renal inner medullary mIMCD3 cell line. Am J Physiol. 1999 Aug;277(2):F176-85. [8]Ogino Y, et al., Effects of chronic, urea-induced osmotic diuresis on kidney weight and function in rats. Diabetologia. 1994 Mar;37(3):225-31.
Smiles	NC(N)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Carbonyl diamide
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Carbonic Anhydrase; Endogenous Metabolite; ERK
Shipping Temperature	Room Temperature
Storage Conditions	Store at room temperature 3 years
Molecular Weight	60.06
Product Description	Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Isoform	Human Endogenous Metabolite; Microbial Metabolite
Clinical information	Launched

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