Thapsigargin Epoxide

Non Antibodies

SERCA

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

632, 75

A Nonactive Analogue of Thapsigargin

DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

100 nM.

DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Thapsigargin, derived from the plant genus Thapsia1, 2, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent that induces rapid Ca2+ release from intracellular stores3 by the inhibition of the sarcoplasmic endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation4. Thapsigargin-induced depletion of Ca2+ stores causes apoptosis in most cell lines5. It has also been shown to cause histamine secretion from rat mast cells6 and to stimulate arachidonic acid metabolism in macrophages7. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in the skin8.Thapsigargin Epoxide is a non-active analogue of Thapsigargin and can be used as a negative control for Thapsigargin activity9, 10.