Calcimycin

52665-69-7

523.62

DMSO : 50 mg/mL (95.49 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)

Anti-infection; Apoptosis; Anti-infection; Autophagy; Anti-infection

Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis^[1][2][3][4]. In Vitro: Calcimycin (A-23187) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner^[4]. In Vivo: Calcimycin (A-23187) (2.5 or 7.5 nM; intrapleurally) induces protein leakage^[5].