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KCC2 blocker 1

KCC2 blocker 1

Item no.	CS-0007490-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Neuroscience Neural Signaling Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1228439-36-8
Similar products	1228439-36-8
Available
CAS	1228439-36-8
Purity	>98%
MWt	415.50
Formula	C22H25NO5S
Solubility	DMSO : 250 mg/mL (601.68 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Membrane Transporter/Ion Channel
Target	Potassium Channel
Biological Activity	KCC2 blocker 1 is an orally active and selective K⁺-Cl^- cotransporter KCC2 blocker with an IC₅₀ of 1 uM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect^[1]. IC50 & Target: IC50: 1 uM (KCC2)^[1] In Vitro: KCC2 blocker 1 (compound 13; 100 uM) inhibits NKCC1 with 35%. In Vivo: KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t_1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C _max of 457 ng/mL and a AUC of 726 ng-h/mL for male Wistar rats^[1].
Research Area	Neurological Disease

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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