trans-Zeatin

1637-39-4

C10H13N5O

DMSO : >= 60 mg/mL (273.67 mM)

Stem Cell/Wnt; MAPK/ERK Pathway; MAPK/ERK Pathway

trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation. IC50 & Target: MEK/ERK^[2] In Vitro: trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division^[1]. trans-Zeatin (20, 40 or 80 uM) inhibits UV-induced MEK/ERK activation, upregulates AQP3 in a time- and dose-dependent manner, and attenuates UV induced loss of AQP3 in keratinocytes (HaCaT cells). UV-induced AQP3 downregulation is blocked by MEK/ERK inhibitors. Trans-Zeatin (80 uM) attenuates UV-induced downregulation of wound healing and water permeability in HaCaT cells^[2].